Copied!

Pathway Search



streptomycin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
CDP-glucose <=> CDP-N-methyl-L-glucosamine not assigned

1-amino-1-deoxy-scyllo-inositol + ATP <=> H+ + 1-amino-1-deoxy-scyllo-inositol_4-phosphate + ADP 2.7.1.65 scyllo-inosamine 4-kinase

dihydrostreptomycin_6-phosphate + acceptor <=> streptomycin_6-phosphate + reduced_acceptor not assigned

scyllo-inosose + L-glutamine <=> 1-amino-1-deoxy-scyllo-inositol + 2-Oxoglutaramate 2.6.1.50 glutamine---scyllo-inositol transaminase

alpha-D-glucose_1-phosphate <=> D-glucose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.3 phosphoacetylglucosamine mutase
5.4.2.5 phosphoglucomutase (glucose-cofactor)
5.4.2.8 phosphomannomutase





(1S,2R,3S,4S,5R,6S)-4-amino-2-carbamimidamido-3,5,6-trihydroxycyclohexyl_phosphate + L-arginine <=> streptidine_6-phosphate + L-ornithine not assigned

L-arginine + 1-amino-1-deoxy-scyllo-inositol_4-phosphate <=> 1-guanidino-1-deoxy-scyllo-inositol_4-phosphate + L-ornithine 2.1.4.2 scyllo-inosamine-4-phosphate amidinotransferase

streptidine_6-phosphate + dTDP-L-dihydrostreptose <=> H+ + O-1,4-alpha-L-dihydrostreptosyl-streptidine_6-phosphate + dTDP 2.4.2.27 dTDP-dihydrostreptose---streptidine-6-phosphate dihydrostreptosyltransferase

O-1,4-alpha-L-dihydrostreptosyl-streptidine_6-phosphate + CDP-N-methyl-L-glucosamine <=> H+ + dihydrostreptomycin_6-phosphate + CDP not assigned

H+ + alpha-D-glucose_1-phosphate + CTP <=> CDP-glucose + diphosphate 2.7.7.24 glucose-1-phosphate thymidylyltransferase
2.7.7.33 glucose-1-phosphate cytidylyltransferase
2.7.7.9 UTP---glucose-1-phosphate uridylyltransferase



dTDP-L-rhamnose <=> dTDP-L-dihydrostreptose not assigned

1-guanidino-1-deoxy-scyllo-inositol + acceptor <=> 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + reduced_acceptor not assigned

myo-inositol + NAD+ <=> scyllo-inosose + NADH + H+ 1.1.1.114 apiose 1-reductase
1.1.1.18 inositol 2-dehydrogenase


streptomycin + ATP <=> H+ + streptomycin_6-phosphate + ADP 2.7.1.72 streptomycin 6-kinase

1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + ATP <=> H+ + (1S,2R,3S,4S,5R,6S)-4-amino-2-carbamimidamido-3,5,6-trihydroxycyclohexyl_phosphate + ADP 2.7.1
2.7.1.65 scyllo-inosamine 4-kinase


H2O + streptomycin_6-phosphate <=> phosphate + streptomycin 3.1.3.39 streptomycin-6-phosphatase

pyruvate + 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol <=> L-alanine + 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol 2.6.1.56 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase

H2O + 1-guanidino-1-deoxy-scyllo-inositol_4-phosphate <=> phosphate + 1-guanidino-1-deoxy-scyllo-inositol 3.1.3.40 guanidinodeoxy-scyllo-inositol-4-phosphatase

Visualization of the pathway